Keqiang Ye Selected Research

6,7-dihydroxyflavone

1/2021	7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis.
1/2021	Crosstalk between the muscular estrogen receptor α and BDNF/TrkB signaling alleviates metabolic syndrome via 7,8-dihydroxyflavone in female mice.
1/2018	The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer's disease.
3/2015	Activation of muscular TrkB by its small molecular agonist 7,8-dihydroxyflavone sex-dependently regulates energy metabolism in diet-induced obese mice.
2/2014	7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease.
3/2012	7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome.
2/2010	A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone.

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Keqiang Ye Research Topics

Disease

39	Alzheimer Disease (Alzheimer's Disease) 08/2022 - 02/2014
36	Neoplasms (Cancer) 01/2021 - 10/2002
17	Cognitive Dysfunction 11/2022 - 01/2016
16	Parkinson Disease (Parkinson's Disease) 01/2022 - 02/2010
9	Glioblastoma (Glioblastoma Multiforme) 04/2022 - 01/2005
7	Inflammation (Inflammations) 11/2022 - 05/2009
7	Insulin Resistance 08/2022 - 04/2010
7	Amyloid Plaque 01/2022 - 01/2018
6	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 10/2007
5	Obesity 01/2022 - 04/2010
5	Brain Neoplasms (Brain Tumor) 01/2020 - 01/2005
5	Memory Disorders (Memory Loss) 01/2019 - 02/2014
4	Motor Disorders 01/2022 - 11/2019
4	Ischemia 01/2018 - 03/2008
4	Stroke (Strokes) 10/2016 - 10/2007
3	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 01/2015
3	Constipation 12/2021 - 01/2020
3	Type 2 Diabetes Mellitus (MODY) 01/2021 - 07/2011
3	Breast Neoplasms (Breast Cancer) 01/2021 - 11/2011
3	Infarction (Infarctions) 01/2015 - 10/2007
2	Peripheral Nerve Injuries 01/2022 - 01/2021
2	Body Weight (Weight, Body) 01/2022 - 10/2018
2	Neoplasm Metastasis (Metastasis) 01/2021 - 01/2017
2	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2019 - 08/2012
2	Hyperlipidemias (Hyperlipidemia) 10/2018 - 01/2017
2	Infections 01/2018 - 05/2009
2	Synucleinopathies 08/2017 - 01/2017
2	Carcinogenesis 11/2015 - 08/2013
2	Leukemia 08/2014 - 06/2008
2	Ganglion Cysts (Ganglion) 01/2014 - 07/2010
2	Nervous System Diseases (Neurological Disorders) 10/2012 - 01/2012
2	Neurofibromatosis 2 (Neurofibromatosis Type II) 12/2004 - 11/2004

Drug/Important Bio-Agent (IBA)

28	asparaginylendopeptidase (legumain)IBA 11/2022 - 01/2009
21	Proteins (Proteins, Gene)FDA Link 01/2022 - 09/2005
18	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2022 - 07/2010
17	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2022 - 01/2017
12	Amyloid (Amyloid Fibrils)IBA 01/2022 - 11/2015
10	Phosphotransferases (Kinase)IBA 01/2022 - 10/2002
10	SynucleinsIBA 01/2021 - 01/2017
9	Peptide Hydrolases (Proteases)FDA Link 01/2021 - 01/2007
7	6,7-dihydroxyflavoneIBA 01/2021 - 02/2010
6	trkB ReceptorIBA 01/2022 - 03/2012
6	Netrin-1IBA 01/2022 - 01/2015
6	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2019 - 03/2009
5	LipidsIBA 01/2022 - 05/2009
5	Transcription Factors (Transcription Factor)IBA 10/2021 - 01/2018
5	Neurofibromin 2 (Merlin)IBA 11/2011 - 11/2004
4	EnzymesIBA 11/2022 - 11/2012
4	Apolipoprotein E4IBA 01/2022 - 01/2021
4	AMP-Activated Protein KinasesIBA 01/2022 - 04/2010
4	LigandsIBA 01/2022 - 06/2011
4	CytokinesIBA 01/2021 - 01/2017
4	Dopamine (Intropin)FDA LinkGeneric 11/2019 - 12/2015
4	Protein Isoforms (Isoforms)IBA 12/2018 - 01/2005
4	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 03/2010 - 12/2004
3	Insulin (Novolin)FDA Link 08/2022 - 04/2014
3	Noscapine (Narcotine)IBA 04/2022 - 10/2002
3	Carrier Proteins (Binding Protein)IBA 01/2022 - 07/2006
3	ProdrugsIBA 01/2022 - 10/2016
3	Protein Kinases (Protein Kinase)IBA 01/2022 - 01/2013
3	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2022 - 01/2021
3	Small Interfering RNA (siRNA)IBA 10/2020 - 11/2012
3	ErbB Receptors (EGF Receptor)IBA 10/2020 - 02/2012
3	Biomarkers (Surrogate Marker)IBA 01/2020 - 01/2019
3	Pharmaceutical PreparationsIBA 01/2020 - 10/2012
3	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 11/2019 - 12/2015
3	Neuroprotective AgentsIBA 01/2018 - 12/2015
2	ElementsIBA 01/2022 - 01/2021
2	Oxidoreductases (Dehydrogenase)IBA 01/2022 - 01/2020
2	CholesterolIBA 01/2022 - 01/2021
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2022 - 01/2017
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 01/2021
2	NetrinsIBA 01/2022 - 06/2011
2	Apolipoproteins E (ApoE)IBA 10/2021 - 01/2018
2	ApolipoproteinsIBA 10/2021 - 01/2021
2	RotenoneIBA 01/2021 - 01/2020
2	TropomyosinIBA 01/2021 - 05/2016
2	Netrin ReceptorsIBA 01/2021 - 01/2020
2	NeurotoxinsIBA 01/2020 - 11/2019
2	Amyloid beta-PeptidesIBA 12/2018 - 10/2018
2	Glucose (Dextrose)FDA LinkGeneric 10/2018 - 04/2010
2	alpha-Linolenic Acid (Linolenic Acid)IBA 10/2016 - 01/2016
2	Oxidopamine (6 Hydroxydopamine)IBA 01/2016 - 12/2015
2	Phosphogluconate Dehydrogenase (Dehydrogenase, Phosphogluconate)IBA 11/2015 - 08/2014
2	epidermal growth factor receptor VIIIIBA 07/2013 - 02/2012
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 07/2013 - 01/2007
2	Serine (L-Serine)FDA Link 01/2013 - 06/2008
2	Arginine (L-Arginine)FDA Link 01/2013 - 06/2008
2	Nuclear Proteins (Protein, Nuclear)IBA 08/2012 - 09/2005
2	TOR Serine-Threonine KinasesIBA 02/2012 - 11/2007
2	Kainic Acid (Kainate)IBA 02/2010 - 10/2007
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 05/2008 - 12/2004
2	GTP Phosphohydrolases (GTPases)IBA 05/2008 - 11/2005
2	Guanosine Triphosphate (GTP)IBA 01/2005 - 05/2004
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 11/2022
1	LipopolysaccharidesIBA 08/2022

Therapy/Procedure

6	Therapeutics 01/2022 - 11/2007
6	Oral Administration 12/2021 - 02/2012
2	Radiotherapy 05/2016 - 05/2009
2	Drug Therapy (Chemotherapy) 05/2009 - 01/2007